氢化可的松对炎症反应调节的影响。
Influence of hydrocortisone on the modulation of the inflammatory response.
作者信息
Tolone G, Bonasera L, Tolone C
出版信息
Br J Exp Pathol. 1978 Aug;59(4):366-72.
Abstract
In vitro hydrocortisone, in pharmacologically attainable concentrations, binds nonspecifically to rat peritoneal mast cells and amplifies the stimulating effects of PGE1 on membrane-bound adenylate cyclase. As a consequence, the intracellular concentration of cyclic AMP in the target cells increases and histamine release is markedly reduced. Deoxycorticosterone, at the same concentrations, has no effect. These findings may in part explain the mechanism of action of anti-inflammatory steroids, possibly related to the modulating effects of E-type prostaglandins.
摘要
在体外，药理上可达到的浓度的氢化可的松非特异性地结合到大鼠腹膜肥大细胞上，并增强前列腺素E1对膜结合腺苷酸环化酶的刺激作用。结果，靶细胞中环磷酸腺苷的细胞内浓度增加，组胺释放明显减少。相同浓度的脱氧皮质酮则无此作用。这些发现可能部分解释了抗炎类固醇的作用机制，可能与E型前列腺素的调节作用有关。
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