用于早期胎儿丢失细胞遗传学评估的尸检绒毛取样：一种简单可靠的方法。
Postmortem chorionic villus sampling for cytogenetic evaluation of early fetal loss: a simple reliable method.
作者信息
Chen H Y, Yang T C, Yah L S, Hsu T Y, Tsai H D, Chang K S, Hung K S
机构信息
Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan, R.O.C.
出版信息
Zhonghua Yi Xue Za Zhi (Taipei). 1994 Feb;53(2):91-4.
BACKGROUND
Early fetal losses associated with chromosome abnormalities produce most spontaneous abortions. It is not feasible to conduct cytogenetic studies with tissue culture postmortem because of tissue maceration and autolysis.
METHODS
A total of 30 specimens from early fetal losses were karyotyped for chromosomal study. Success rate of the culture method is evaluated and compared.
RESULTS
The abnormal karyotype rate was 33.3%. It was found that chorionic villus tissues had a higher culture rate than tests of fetal skin, amnion or amniocyte by early amniocentesis.
CONCLUSIONS
Postmortem chorionic villus sampling at the time of diagnosis of early fetal death appears to offer the best, most simple and reliable method for obtaining a cytogenetic result, and also a good method for training residents in the chorionic villus sampling technique.
背景
与染色体异常相关的早期胎儿丢失导致了大多数自然流产。由于组织浸软和自溶，死后通过组织培养进行细胞遗传学研究是不可行的。
方法
对30例早期胎儿丢失的标本进行染色体核型分析以进行染色体研究。评估并比较培养方法的成功率。
结果
异常核型率为33.3%。发现绒毛膜绒毛组织的培养率高于早期羊膜穿刺术对胎儿皮肤、羊膜或羊水细胞的检测。
结论
在诊断早期胎儿死亡时进行死后绒毛膜绒毛取样似乎是获得细胞遗传学结果的最佳、最简便且可靠的方法，也是培训住院医师绒毛膜绒毛取样技术的好方法。
Zotero 插件