Abu-Musa A, Takahashi K, Okada S, Sakoda R, Kitao M
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
J Reprod Med. 1994 Jan;39(1):10-2.
The effect of serum from patients with threatened abortion on in vitro development of two-cell mouse embryos was evaluated. Embryos were cultured for 72 hours in 7.5% serum supplement from patients with threatened abortion and from women with normal pregnancies and in Ham's F-10 medium with no serum supplement. Significantly fewer embryos developed to the blastocyst stage at 72 hours in the threatened abortion group as compared with the normal pregnancy group and Ham's F-10 (P < .001). These results suggest the presence of serum factors that are toxic to early embryonic development and thus may play a role in the pathogenesis of threatened abortion.
评估了先兆流产患者血清对二细胞期小鼠胚胎体外发育的影响。将胚胎分别培养于添加7.5%先兆流产患者血清及正常妊娠妇女血清的培养基中，以及无血清添加的Ham's F-10培养基中，共培养72小时。与正常妊娠组和Ham's F-10组相比，先兆流产组在72小时时发育至囊胚期的胚胎数量显著减少（P < .001）。这些结果提示存在对早期胚胎发育有毒性的血清因子，其可能在先兆流产的发病机制中起作用。
