Kondo E, Kiyama H, Araki T, Shida T, Ueda Y, Tohyama M
Department of Anatomy and Neuroscience, Osaka University Medical School, Japan.
Brain Res Mol Brain Res. 1994 Feb;21(3-4):363-7. doi: 10.1016/0169-328x(94)90269-0.
We examined the expression of gamma-aminobutyric acid (GABA)A receptor gamma 1 and gamma 2 subunit mRNAs in the rat trigeminal ganglion using in situ hybridization histochemistry. Most ganglion cells expressed both gamma 1 and gamma 2 mRNAs simultaneously. These findings are a marked contrast to the findings in the central nervous system where areas expressing both subunits are rare. In addition, we demonstrated using immunohistochemistry that the gamma 1 subunit is also expressed at the protein level in trigeminal ganglion neurons and fibers in the trigeminal spinal nucleus.
我们采用原位杂交组织化学方法检测了大鼠三叉神经节中γ-氨基丁酸（GABA）A受体γ1和γ2亚基mRNA的表达。大多数神经节细胞同时表达γ1和γ2 mRNA。这些发现与中枢神经系统中同时表达这两个亚基的区域很少的情况形成了鲜明对比。此外，我们通过免疫组织化学证明，γ1亚基在三叉神经节神经元和三叉神经脊髓核的纤维中也在蛋白质水平表达。
