Uriarte J, Gracia M J, Almeria S
Unidad de Sanidad Animal, Parasitologïa, Servicio de Investigación Agraria (D.G.A.), Zaragoza, Spain.
Vet Parasitol. 1994 Feb;51(3-4):301-5. doi: 10.1016/0304-4017(94)90168-6.
The efficacy of moxidectin against gastrointestinal nematode infections was studied in 30 Fleischschaf x Rasa Aragonesa male lambs aged 3 months at the beginning of the experiment. The lambs were distributed in three groups of 10 animals each and experimentally infected with a mixture of an equal number of infective (L3) larvae from each of the following species: Haemonchus contortus (2000), Ostertagia circumcincta (2000), Trichostrongylus colubriformis (2000) and Trichostrongylus vitrinus (2000). Two groups of lambs were drenched with 0.2 mg moxidectin per kg body weight at 6 (Group B) and 21 (Group C) days post challenge while the third group of animals (Group A) remained untreated. The efficacy of the treatment based on worm counts 4 weeks post infection was of 100% against 4th stage larvae of all species and 100%, 99.98%, 100% and 100% against adults of H. contortus, O. circumcincta, T. colubriformis and T. vitrinus, respectively. Significant differences were found in daily weight gain between treated (Group B+C, 157.9 g day-1) and untreated lambs (Group A, 116 g day-1). No differences in feeding behaviour or health condition between treated and untreated lambs were observed.
在实验开始时，对30只3月龄的弗赖施夏夫×阿拉贡纳萨雄性羔羊进行了莫西菌素抗胃肠道线虫感染疗效的研究。将羔羊分成三组，每组10只，并对其进行实验性感染，感染源为以下每种线虫等量的感染性（L3）幼虫混合物：捻转血矛线虫（2000条）、环形奥斯特线虫（2000条）、蛇形毛圆线虫（2000条）和透明毛圆线虫（2000条）。两组羔羊分别在攻虫后6天（B组）和21天（C组）按每千克体重0.2毫克莫西菌素进行灌服，而第三组动物（A组）不进行治疗。基于感染后4周的虫体计数，该治疗方法对所有线虫的第4期幼虫的疗效为100%，对捻转血矛线虫、环形奥斯特线虫、蛇形毛圆线虫和透明毛圆线虫成虫的疗效分别为100%、99.98%、100%和100%。在日增重方面，治疗组（B组+C组，157.9克/天）和未治疗的羔羊（A组，116克/天）之间存在显著差异。未观察到治疗组和未治疗组羔羊在采食行为或健康状况上有差异。
