Garrel D R, de Jonge L
Department of Nutrition, University of Montréal Medical School, Québec, Canada.
Am J Clin Nutr. 1994 May;59(5):971-4. doi: 10.1093/ajcn/59.5.971.
The aim of this study was to observe the effects of oropharyngeal stimulation on thermogenic response to feeding (TRF) in obese and healthy individuals. Resting energy expenditure was measured in eight normal-weight (BMI, in kg/m2: 22.9 +/- 1.7) and nine obese subjects (BMI: 36.5 +/- 7.2), once after the ingestion of a standardized meal and once after the intragastric administration of the same, blenderized meal. In control subjects, TRF was lower after intragastric than after oral feeding: 5.6 +/- 1.4% vs 8.0 +/- 1.8% of the ingested energy for intragastric vs oral feeding, respectively (P < 0.01), but in obese subjects no difference occurred (6.5 +/- 3.0% vs 6.1 +/- 2.0%). In obese subjects the response over 6 h after the oral meal was lower than in/control subjects (P < 0.01). Intragastric TRF was not different between the two groups. This study confirms our previous observation that TRF has two components in humans, and suggests that oropharyngeal stimulation elicits a greater TRF in normal-weight than in obese individuals.
本研究旨在观察口咽刺激对肥胖个体和健康个体进食产热反应（TRF）的影响。对8名正常体重受试者（体重指数，单位为kg/m2：22.9±1.7）和9名肥胖受试者（体重指数：36.5±7.2）测量静息能量消耗，一次在摄入标准化餐食后，一次在胃内给予相同的经搅拌的餐食后。在对照受试者中，胃内给药后的TRF低于经口进食后：胃内给药与经口进食时分别为摄入能量的5.6±1.4%和8.0±1.8%（P<0.01），但在肥胖受试者中未出现差异（6.5±3.0%对6.1±2.0%）。在肥胖受试者中，经口进食后6小时内的反应低于对照受试者（P<0.01）。两组间胃内TRF无差异。本研究证实了我们之前的观察结果，即人类的TRF有两个组成部分，并表明口咽刺激在正常体重个体中比在肥胖个体中引发更大的TRF。
