Korbet S M, Schwartz M M, Lewis E J
Department of Medicine, Rush Presbyterian St Lukes Medical Center, Chicago, IL.
Am J Kidney Dis. 1994 May;23(5):751-65. doi: 10.1016/s0272-6386(12)70290-1.
Fibrillary glomerulopathy is a category of glomerular disease that is defined by the ultrastructural feature of organized deposits of extracellular, nonbranching, microfibrils. The best-known disease in this category is amyloidosis, but cryoglobulinemia, light chain deposition disease, systemic lupus erythematosus, immunotactoid glomerulopathy, and diabetic fibrillosis may have similar ultrastructural findings and comprise the differential diagnosis of the fibrillary glomerulopathies. Because they have disease-specific therapeutic and prognostic implications, differentiating among these entities is important for nephrologists and nephropathologists. To aid the physician, we will review the fibrillary glomerulopathies using an algorithm based on morphology, clinical features, and serologic assessment. We believe this approach will prove to be practical and useful to the practicing nephrologist.
纤维性肾小球病是一类肾小球疾病，其定义为细胞外、无分支微纤维有序沉积的超微结构特征。该类别中最著名的疾病是淀粉样变性，但冷球蛋白血症、轻链沉积病、系统性红斑狼疮、免疫触须样肾小球病和糖尿病性纤维样病变可能有相似的超微结构表现，构成纤维性肾小球病的鉴别诊断。由于它们具有疾病特异性的治疗和预后意义，区分这些实体对肾病学家和肾病理学家很重要。为帮助医生，我们将使用基于形态学、临床特征和血清学评估的算法来回顾纤维性肾小球病。我们相信这种方法对执业肾病学家将被证明是实用且有用的。
