Baggiolini M, Dahinden C A
Theodor-Kocher Institute, University of Bern, Switzerland.
Immunol Today. 1994 Mar;15(3):127-33. doi: 10.1016/0167-5699(94)90156-2.
CC chemokines are small inducible proteins that are related to interleukin 8. Recent studies have shown that several CC chemokines, MCP-1, MCP-3, RANTES and MIP-1 alpha, act on basophils and/or eosinophils via GTP-binding protein-coupled receptors. Marco Baggiolini and Clemens Dahinden discuss the involvement of CC chemokines in the recruitment and activation of the main effector cells of allergic inflammation.
CC趋化因子是与白细胞介素8相关的可诱导的小蛋白。最近的研究表明，几种CC趋化因子，即单核细胞趋化蛋白-1（MCP-1）、单核细胞趋化蛋白-3（MCP-3）、调节激活正常T细胞表达和分泌因子（RANTES）和巨噬细胞炎性蛋白-1α（MIP-1α），通过GTP结合蛋白偶联受体作用于嗜碱性粒细胞和/或嗜酸性粒细胞。马尔科·巴廖尼和克莱门斯·达欣登讨论了CC趋化因子在过敏性炎症主要效应细胞的募集和激活中的作用。
