Vattimo A, Burroni L, Bertelli P, Messina M, Meucci D, Tota G
Nuclear Medicine Unit, University of Siena, Italy.
J Nucl Biol Med (1991). 1993 Dec;37(4):218-22.
Serial colon scintigraphy using 111In-DTPA (2 MBq) given orally was performed in 39 children referred for constipation, and the total and segmental colon transit times were measured. The bowel movements during the study were recorded and the intervals between defecations (ID) were calculated. This method proved able to identify children with normal colon morphology (no. = 32) and those with dolichocolon (no. = 7). Normal children were not included for ethical reasons and we used the normal range determined by others using x-ray methods (29 +/- 4 hours). Total and segmental colon transit times were found to be prolonged in all children with dolichocolon (TC: 113.55 +/- 41.20 hours; RC: 39.85 +/- 26.39 hours; LC: 43.05 +/- 18.30 hours; RS: 30.66 +/- 26.89 hours). In the group of children with a normal colon shape, 13 presented total and segmental colon transit times within the referred normal value (TC: 27.79 +/- 4.10 hours; RC: 9.11 +/- 2.53 hours; LC: 9.80 +/- 3.50 hours; RS: 8.88 +/- 4.09 hours) and normal bowel function (ID: 23.37 +/- 5.93 hours). In the remaining children, 5 presented prolonged retention in the rectum (RS: 53.36 +/- 29.66 hours), and 14 a prolonged transit time in all segments. A good correlation was found between the transit time and bowel function. From the point of view of radiation dosimetry, the most heavily irradiated organs were the lower large intestine and the ovaries, and the level of radiation burden depended on the colon transit time. We can conclude that the described method results safe, accurate and fully diagnostic.
对39名因便秘前来就诊的儿童进行了口服111铟-二乙三胺五乙酸（2兆贝可）的连续结肠闪烁扫描，并测量了全结肠和节段性结肠转运时间。记录研究期间的排便情况，并计算排便间隔时间（ID）。该方法被证明能够识别结肠形态正常的儿童（n = 32）和患有冗长结肠的儿童（n = 7）。出于伦理原因，未纳入正常儿童，我们采用了其他人用X射线方法确定的正常范围（29±4小时）。发现所有患有冗长结肠的儿童全结肠和节段性结肠转运时间均延长（全结肠：113.55±41.20小时；右半结肠：39.85±26.39小时；左半结肠：43.05±18.30小时；直肠乙状结肠：30.66±26.89小时）。在结肠形状正常的儿童组中，13名儿童的全结肠和节段性结肠转运时间在所述正常范围内（全结肠：27.79±4.10小时；右半结肠：9.11±2.53小时；左半结肠：9.80±3.50小时；直肠乙状结肠：8.88±4.09小时）且肠道功能正常（排便间隔时间：23.37±5.93小时）。在其余儿童中，5名儿童直肠滞留时间延长（直肠乙状结肠：53.36±29.66小时），14名儿童所有节段的转运时间均延长。发现转运时间与肠道功能之间存在良好的相关性。从辐射剂量学的角度来看，受辐射最严重的器官是下大肠和卵巢，辐射负担水平取决于结肠转运时间。我们可以得出结论，所述方法结果安全、准确且具有充分的诊断性。
