Roberts J P, Newell M S, Deeks J J, Waldron D W, Garvie N W, Williams N S
Surgical Unit, Royal London Hospital, UK.
Dig Dis Sci. 1993 Jun;38(6):1032-9. doi: 10.1007/BF01295718.
Patterns of colonic transit were assessed by a simple radioisotopic technique using 3.7 MBq of orally administered [111In]DTPA in 16 control subjects and 37 patients with intractable constipation. Normal subjects showed rapid diffuse spread of isotope through the colon resulting in low activity in all regions of interest (ROI). Activity was lost to feces at 24 hr and was virtually complete by 72 hr (median 94%, range 71-100%). Five constipated patients showed normal transit. Those with colonic inertia (N = 26) showed a significantly slowed geometric center of isotope compared to controls (P < 0.001), falling below the normal range at 48 hr. Percentage activity curves showed the major site of isotope hold-up to be in the transverse colon and splenic flexure. Other constipated patients (N = 6) showed late delay of the geometric center of isotope and accumulation of activity in the descending and rectosigmoid colon, compared to controls, at 96 hr. Oral [111In]DTPA colonic scintigraphy is a useful clinical test in the investigation of constipation.
采用简单的放射性同位素技术评估结肠传输模式，对16名对照受试者和37名顽固性便秘患者口服3.7 MBq的[111In]二乙三胺五乙酸（DTPA）。正常受试者显示同位素在结肠内快速弥漫性扩散，导致所有感兴趣区域（ROI）的活性较低。24小时时，活性随粪便排出，到72小时时基本完成（中位数94%，范围71 - 100%）。5名便秘患者显示传输正常。结肠无力患者（N = 26）与对照组相比，同位素的几何中心明显减慢（P < 0.001），在48小时时低于正常范围。百分比活性曲线显示同位素滞留的主要部位在横结肠和脾曲。其他便秘患者（N = 6）与对照组相比，在96小时时同位素几何中心延迟较晚，且降结肠和直肠乙状结肠交界处有活性积聚。口服[111In]DTPA结肠闪烁扫描是便秘检查中一项有用的临床检查。
