McLean R G, Smart R C, Gaston-Parry D, Barbagallo S, Baker J, Lyons N R, Bruck C E, King D W, Lubowski D Z, Talley N A
Department of Nuclear Medicine, St. George Hospital, Kogarah, New South Wales, Australia.
J Nucl Med. 1990 Jun;31(6):985-9.
The purpose of the study was to assess if a new scintigraphic method for noninvasive assessment of colonic transit could differentiate between subjects with normal bowel transit and those with constipation. Eleven normal subjects and 29 constipated patients were given 4 MBq iodine-131-cellulose (131I-cellulose) orally and sequential abdominal scans were performed at 6, 24, 48, 72, and 96 hr from which total and segmental percent retentions were calculated. There were clear differences between the normal subjects and the constipated patients for the total percent retention at all time intervals, on a segmental basis in the right colon at 24 hr, and in all segments at 48 and 72 hr. Three-day urinary excretion of radioiodine was minimal; 2.4% +/- 1.2% (mean +/- s.d.) in constipated patients and 3.1% +/- 0.8% in normals, with approximately 75% occurring in the first day. The use of oral radiotracers in the investigation of constipation appears promising.
本研究的目的是评估一种用于非侵入性评估结肠转运的新闪烁扫描方法能否区分肠道转运正常的受试者和便秘患者。11名正常受试者和29名便秘患者口服4MBq碘-131纤维素（131I-纤维素），并在6、24、48、72和96小时进行连续腹部扫描，计算总保留率和节段保留率。在所有时间间隔的总保留率、24小时时右半结肠节段性保留率以及48和72小时时所有节段的保留率方面，正常受试者和便秘患者之间存在明显差异。放射性碘的三日尿排泄量极少；便秘患者为2.4%±1.2%（均值±标准差），正常人为3.1%±0.8%，约75%在第一天排出。口服放射性示踪剂用于便秘研究似乎很有前景。
