Gerritsma E J, Brocaar M P, Hakkesteegt M M, Birkenhäger J C
Department of Phoniatrics, Oto-Rhino-Laryngology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Clin Otolaryngol Allied Sci. 1994 Feb;19(1):79-84. doi: 10.1111/j.1365-2273.1994.tb01153.x.
In a prospective study the effects on the voice of nandrolone decanoate super-imposed on cyclical hormonal replacement therapy (HRT) given to post-menopausal women suffering from a severe form osteoporosis were compared with the effects of HRT alone. Comparing the experimental group with the control group, after one year of medication in the experimental group a higher percentage of patients had: a lower fundamental frequency during speech, a loss of high frequencies and an increase in voice instability and creakiness. The lowering of the frequencies and the increase of instability can be explained by histological changes in the vocal cords and by problems in the adaptation to these histological changes.
在一项前瞻性研究中，将癸酸诺龙叠加于接受周期性激素替代疗法（HRT）的严重骨质疏松绝经后女性的声音影响，与单独使用HRT的效果进行了比较。将实验组与对照组进行比较，实验组用药一年后，更高比例的患者出现：说话时基频降低、高频丧失、声音不稳定性和粗糙感增加。频率降低和不稳定性增加可通过声带的组织学变化以及对这些组织学变化的适应问题来解释。
