Vermersch P, Scheltens P, Barkhof F, Steinling M, Leys D
Department of Neurology, University of Lille, France.
Eur Neurol. 1994;34(2):83-6. doi: 10.1159/000117014.
Patients with late-onset Alzheimer's disease (AD) have more white matter changes on magnetic resonance imaging (MRI) than controls. To test the hypothesis that AD patients might have also atrophy of the corpus callosum (CC), we compared the CC thickness on MRI from 20 AD patients and 21 controls. We found a significant reduction in the CC thickness in AD compared with age-matched controls (p < 0.01). We demonstrated that atrophy of the CC depends mainly on the diagnosis of senile dementia of the Alzheimer type and at a lower degree on the diagnosis of presenile AD but neither on age nor on ventricle enlargement. This result suggests that beside the greater severity of white matter involvement in late-onset AD, atrophy of the CC may also be present.
晚发性阿尔茨海默病（AD）患者在磁共振成像（MRI）上的白质变化比对照组更多。为了验证AD患者可能也存在胼胝体（CC）萎缩这一假设，我们比较了20例AD患者和21例对照组的MRI上CC厚度。我们发现，与年龄匹配的对照组相比，AD患者的CC厚度显著降低（p < 0.01）。我们证明，CC萎缩主要取决于阿尔茨海默型老年性痴呆的诊断，在较低程度上取决于早发性AD的诊断，但既不取决于年龄也不取决于脑室扩大。这一结果表明，除了晚发性AD中白质受累程度更严重外，CC萎缩也可能存在。
