Loganath A, Gunasegaram R, Peh K L, Chow W P, Chew P C, Shanmugaratnam S
Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Fertil Steril. 1994 May;61(5):990-2. doi: 10.1016/s0015-0282(16)56721-1.
In an attempt to determine whether human spermatozoa contain steroid hormones, in this study we have measured the immunoreactive levels of P, 17 alpha-OHP, and F in the extracts of sonicated specimens of sperms obtained as ejaculates from husbands of infertile couples. The results of this study demonstrate for the first time that human spermatozoa contain definite amounts of the measured steroids and suggests an association between steroid levels and sperm count. These steroids identified intracellularly in the haploid germ cells may play a role in the molecular events associated with fertilization.
为了确定人类精子是否含有类固醇激素，在本研究中，我们测量了从不育夫妇的丈夫射出的精液中获取的经超声处理的精子标本提取物中孕酮（P）、17α-羟孕酮（17α-OHP）和雌二醇（F）的免疫反应水平。这项研究的结果首次证明人类精子含有一定量的被测类固醇，并表明类固醇水平与精子数量之间存在关联。这些在单倍体生殖细胞内鉴定出的类固醇可能在与受精相关的分子事件中发挥作用。
