Ponjee G A, Janssen E M, van Wersch J W
Diagnostic Centre SSDZ, Delft, The Netherlands.
Haemostasis. 1993 Sep-Oct;23(5):269-74. doi: 10.1159/000216886.
To study the long-term non-acute effect of endurance physical exercise on blood platelet activation, 20 sedentary males and 14 sedentary females were trained 3 to 4 times a week for 9 months. After 24 weeks all subjects ran a 15-km race; and after 36 weeks a half-marathon (21 km) race. Blood samples were drawn before the training programme and 5 days after both races. Median (interquartile range) platelet factor 4 and beta-thromboglobulin pretraining values for the total group were 9 (5-35) and 69 (40-495) IU/ml, respectively. During the course of the training programme, plasma platelet factor 4 concentrations rose steadily and significantly in both the male and female group (p < 0.05), together with a non-significant rise in plasma beta-thromboglobulin. At the end of the training procedure, 5 days after the half-marathon run, median (interquartile range) plasma factor 4 and beta-thromboglobulin concentrations for the total group were 150 (62-198) and 156 (84-288) IU/ml, respectively. No difference existed in median platelet factor 4 and beta-thromboglobulin concentrations of the male and female population before or during the training programme. In summary, the results of this study demonstrate that prolonged physical conditioning of increasing intensity is mainly associated with an elevation of the platelet protein platelet factor 4.
为研究耐力体育锻炼对血小板活化的长期非急性影响，20名久坐不动的男性和14名久坐不动的女性每周接受3至4次训练，为期9个月。24周后，所有受试者参加了一场15公里的比赛；36周后参加了一场半程马拉松（21公里）比赛。在训练计划开始前以及两场比赛后的第5天采集血样。整个组血小板第4因子和β-血小板球蛋白训练前的中位数（四分位间距）值分别为9（5 - 35）和69（40 - 495）IU/ml。在训练计划过程中，男性和女性组血浆血小板第4因子浓度均稳步且显著上升（p < 0.05），同时血浆β-血小板球蛋白有不显著的上升。在训练程序结束时，即半程马拉松赛后第5天，整个组血浆第4因子和β-血小板球蛋白浓度的中位数（四分位间距）分别为150（62 - 198）和156（84 - 288）IU/ml。在训练计划之前或期间，男性和女性人群的血小板第4因子和β-血小板球蛋白浓度中位数没有差异。总之，本研究结果表明，强度不断增加的长期体育锻炼主要与血小板蛋白血小板第4因子的升高有关。
