Röcker L, Drygas W K, Heyduck B
Eur J Appl Physiol Occup Physiol. 1986;55(4):374-80. doi: 10.1007/BF00422736.
To see whether strenuous prolonged exertion increases blood platelet activation and thrombin activity in healthy well-trained men, 16 male amateur runners (mean age 31,8) were studied. A marathon race (mean time 2 h 44 min 30 s) caused a significant increase in plasma beta-thromboglobulin (beta-TG), platelet factor 4 (PF4), fibrinopetide A (FPA) and factor VIII (F VIII) activity. Sixty min after exertion beta-TG and F VIII activity were still significantly elevated. FPA continued to rise, reaching peak values 60 min after the run. 22 h after finishing the race F VIII activity was still significantly elevated. The study has demonstrated the great inter-individual variability of marathon race-induced haemostatic changes. The elevation of beta-TG varied from 42% to 156%, F VIII from 112% to 625%, and in three runners FPA reached more than 900% of its pre-exercise value. In some individuals the haemostatic changes observed could be potentially unfavourable for coronary heart disease prevention.
为了探究剧烈的长时间运动是否会增加健康且训练有素的男性的血小板活化和凝血酶活性，对16名男性业余跑步者（平均年龄31.8岁）进行了研究。一场马拉松比赛（平均用时2小时44分30秒）导致血浆β-血小板球蛋白（β-TG）、血小板第4因子（PF4）、纤维蛋白肽A（FPA）和凝血因子VIII（F VIII）活性显著增加。运动60分钟后，β-TG和F VIII活性仍显著升高。FPA持续上升，在跑步后60分钟达到峰值。完成比赛22小时后，F VIII活性仍显著升高。该研究表明，马拉松比赛引起的止血变化存在很大的个体差异。β-TG的升高幅度从42%到156%不等，F VIII从112%到625%不等，在三名跑步者中，FPA达到了运动前值的900%以上。在一些个体中，观察到的止血变化可能对预防冠心病有潜在的不利影响。
