Matzkies F
Z Ernahrungswiss. 1975 Sep;14(3):184-216. doi: 10.1007/BF02021198.
Metabolic effects of glucose, fructose, sorbitol, xylitol and their combinations during intravenous application in men were investigated. The totale and metabolic clearance, the renal and metabolic elimination, the half-time and the turnover rate were measured. For all sugars intravenous long-term infusions from six to twelve hours were performed. Up to a dosage of 0.75 g/kg/h for glucose 0.5 g/kg/h for sorbitol and 0.25 g/kg/h for fructose and xylitol a steady state of substrates and metabolites has been found. If these dosage-limits are exceeded during glucose application a hyperglucosemia, after sorbitol a continous rise in sorbitol blood level, during fructose a rise in lactate and during xylitol infusion clinical side effects occurred. It could be shown that during simultaneous application of glucose, fructose and xylitol the utilization of glucose rises whereas the utilization of fructose and xylitol remain on such levels as if these sugar were infused alone.
研究了葡萄糖、果糖、山梨醇、木糖醇及其组合在男性静脉输注期间的代谢效应。测量了总清除率和代谢清除率、肾脏清除和代谢清除、半衰期和周转率。对所有糖类进行了6至12小时的静脉长期输注。对于葡萄糖，剂量高达0.75 g/kg/h；山梨醇为0.5 g/kg/h；果糖和木糖醇为0.25 g/kg/h时，已发现底物和代谢物处于稳态。在输注葡萄糖期间，如果超过这些剂量限制，会出现高血糖症；输注山梨醇后，山梨醇血水平持续升高；输注果糖后，乳酸水平升高；输注木糖醇期间会出现临床副作用。结果表明，在同时输注葡萄糖、果糖和木糖醇时，葡萄糖的利用率会提高，而果糖和木糖醇的利用率则保持在单独输注这些糖类时的水平。
