Hashimoto Y, Takahashi H, Matsuo S, Hirai K, Takemori N, Nakao M, Miyamoto K, Iizuka H
Department of Dermatology, Asahikawa Medical College, Japan.
Dermatology. 1996;192(2):136-9. doi: 10.1159/000246339.
A 49-year-old man presented a progressive swelling and induration of the skin resulting in flexion contracture. He had a history of two tick bites at the age of 17 and 47 years. Serum anti-Borrelia-burgdorferi antibody was positive; isolation of B. burgdorferi from the skin lesion was unsuccessful. He had eosinophilia (white blood cells 8,300/microlitre, 33% eosinophils) and hypergammaglobulinemia. The diagnosis of Shulman syndrome (eosinophilic fasciitis) from clinical and histological findings was established. A part of the flagellin gene of B. burgdorferi was detected in a skin biopsy sample by using the polymerase chain reaction method. To the best of our knowledge, this is the first report of detection of B.-burgdorferi-specific DNA from a skin sample of Shulman syndrome.
一名49岁男性出现皮肤进行性肿胀和硬结，导致屈曲挛缩。他在17岁和47岁时曾有两次蜱虫叮咬史。血清抗伯氏疏螺旋体抗体呈阳性；从皮肤病变中分离出伯氏疏螺旋体未成功。他有嗜酸性粒细胞增多症（白细胞8300/微升，33%为嗜酸性粒细胞）和高球蛋白血症。根据临床和组织学检查结果确诊为舒尔曼综合征（嗜酸性筋膜炎）。通过聚合酶链反应方法在皮肤活检样本中检测到了伯氏疏螺旋体鞭毛蛋白基因的一部分。据我们所知，这是首次从舒尔曼综合征皮肤样本中检测到伯氏疏螺旋体特异性DNA的报告。
