Hamilton C L, Ciaccia P J, Lewis D O
Am J Physiol. 1976 Mar;230(3):818-30. doi: 10.1152/ajplegacy.1976.230.3.818.
In monkeys (Macaca mulatta) without hypothalamic lesions, food intake was found to increase with increasing age and body weight; however, food intake per kilogram body weight showed a decline over the same period of time. As the animals became older, the amount of food intake converted to body weight decreased dramatically (feeding efficiency). Water intake was shown to be closely coupled to food intake. Both daily food and water-intake data were highly reliable over a period of years. Monkeys with ventromedial hypothalamic lesions exhibited hyperphagia and increased feeding-efficiency ratios and eventual obesity. The obese animals developed symptoms of diabetes mellitus. Animals with lesions restricted primarily to the arcuate nucleus showed no hyperphagia but increased feeding efficiency. These animals exhibited decreased growth hormone release and a transitory elevation of serum insulin.
在没有下丘脑损伤的恒河猴（猕猴）中，发现食物摄入量随年龄和体重的增加而增加；然而，每千克体重的食物摄入量在同一时期呈下降趋势。随着动物年龄的增长，转化为体重的食物摄入量大幅减少（喂养效率）。饮水量与食物摄入量密切相关。多年来，每日食物和饮水量数据都高度可靠。患有腹内侧下丘脑损伤的猴子表现出食欲亢进、喂养效率比增加并最终肥胖。肥胖动物出现糖尿病症状。主要局限于弓状核损伤的动物没有食欲亢进，但喂养效率增加。这些动物生长激素释放减少，血清胰岛素短暂升高。
