Novin D, Gonzalez M F, Sanderson J D
Am J Physiol. 1976 Apr;230(4):1084-9. doi: 10.1152/ajplegacy.1976.230.4.1084.
Glucose infusions increased feeding in recovered lateral hypothalamic (LH) lesioned rats in constrast to its suppressant effect in sham-lesioned rats and in rats with lesions unilateral, asymmetrical or anterior to LH. This paradoxical enhancement of eating by glucose was predicted from similar effects seen in vagotomized rabbits and general parallels observed in ingestive behavior after LH lesions and vagotomy. We conclude that an important component in the short-term control of food intake is a vagal-LH circuit and that a modification of the classic notion of the LH as an excitatory "feeding center" is needed.
与葡萄糖对假手术大鼠以及下丘脑外侧区（LH）单侧、不对称或前部损伤大鼠的抑制作用相反，葡萄糖输注增加了下丘脑外侧区损伤恢复大鼠的进食量。葡萄糖这种反常的促进食作用是根据在迷走神经切断的兔子身上观察到的类似效应以及下丘脑外侧区损伤和迷走神经切断后在摄食行为中观察到的一般相似性预测出来的。我们得出结论，食物摄入短期控制中的一个重要组成部分是迷走神经-下丘脑外侧区回路，并且需要修正将下丘脑外侧区视为兴奋性“摄食中枢”的经典概念。
