Rezek M, Novin D
J Nutr. 1976 Jun;106(6):812-20. doi: 10.1093/jn/106.6.812.
A comparative study on the satiating effect of duodenal infusions of glycerol, casein and glucose was performed in intact and vagotomized rabbits during both diuranal and nocturnal periods. All duodenally infused substances had satiating effects. Glycerol infusions produced the largest reduction of food intake during the day while casein hydrolysate infusion was most effective in this respect during the night. The most apparent and consistent effect of vagotomy was the elimination of hypophagic effect of diurnal and nocturnal infusions of glucose. Pretreatment with atropine methyl nitrate, which prevented the evoked gastric contractions in response to electrical stimulation of the efferent cervical vagus nerve in acute preparations but did not influence spontaneous intake in free-feeding animals, had no effect on duodenal glucose induced satiety. This result indicates that afferent vagal mediation of information from peripheral metabolic organs is vital to the short-term glucostatic regulation of food intake.
在完整和迷走神经切断的兔子的昼夜期间，对十二指肠输注甘油、酪蛋白和葡萄糖的饱腹感效应进行了比较研究。所有十二指肠输注物质都有饱腹感效应。白天输注甘油导致食物摄入量减少最多，而夜间输注酪蛋白水解物在这方面最有效。迷走神经切断术最明显和一致的效果是消除了昼夜输注葡萄糖的食欲减退效应。用硝酸甲基阿托品预处理，可防止急性制剂中传出颈迷走神经电刺激引起的胃收缩，但不影响自由进食动物的自发摄入量，对十二指肠葡萄糖诱导的饱腹感没有影响。这一结果表明，来自外周代谢器官的信息通过迷走神经传入介导对食物摄入的短期糖稳态调节至关重要。
