来自凹叶美登木的两种新的大环内酯倍半萜吡啶生物碱：凹叶美登碱G和具有细胞毒性的凹叶美登碱F。

Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F.

作者信息

Kuo Y H, King M L, Chen C F, Chen H Y, Chen C H, Chen K, Lee K H

机构信息

National Research Institute of Chinese Medicine, Shin-Dain, Taipei Hsien, Taiwan.

出版信息

J Nat Prod. 1994 Feb;57(2):263-9. doi: 10.1021/np50104a011.

DOI:10.1021/np50104a011

PMID:8176403

Abstract

Two new macrolide sesquiterpene pyridine alkaloids, emarginatine F [1] and emarginatine G [2], were isolated from Maytenus emarginata. The structural determinations of 1 and 2 by 2D nmr techniques and spectral comparison with a related compound, emarginatine A [3], are discussed. Biological evaluation showed that emarginatine F [1] demonstrated strong cytotoxicity against human epidermoid carcinoma of the nasopharynx (KB), ileocecal adenocarcinoma (HCT-8), melanoma (RPMI-7951) and medulloblastoma (TE-671) tumor cells, and against murine leukemia (P-388).

摘要

从椭圆叶美登木中分离出两种新的大环内酯倍半萜吡啶生物碱，即椭圆叶美登碱F [1]和椭圆叶美登碱G [2]。讨论了通过二维核磁共振技术对1和2进行结构测定以及与相关化合物椭圆叶美登碱A [3]进行光谱比较的情况。生物学评价表明，椭圆叶美登碱F [1]对人鼻咽表皮样癌（KB）、回盲部腺癌（HCT-8）、黑色素瘤（RPMI-7951）和髓母细胞瘤（TE-671）肿瘤细胞以及小鼠白血病（P-388）显示出较强的细胞毒性。