Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F.
作者信息
Kuo Y H, King M L, Chen C F, Chen H Y, Chen C H, Chen K, Lee K H
机构信息
National Research Institute of Chinese Medicine, Shin-Dain, Taipei Hsien, Taiwan.
出版信息
J Nat Prod. 1994 Feb;57(2):263-9. doi: 10.1021/np50104a011.
Two new macrolide sesquiterpene pyridine alkaloids, emarginatine F [1] and emarginatine G [2], were isolated from Maytenus emarginata. The structural determinations of 1 and 2 by 2D nmr techniques and spectral comparison with a related compound, emarginatine A [3], are discussed. Biological evaluation showed that emarginatine F [1] demonstrated strong cytotoxicity against human epidermoid carcinoma of the nasopharynx (KB), ileocecal adenocarcinoma (HCT-8), melanoma (RPMI-7951) and medulloblastoma (TE-671) tumor cells, and against murine leukemia (P-388).
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