Bruceanols D, E, and F three new cytotoxic quassinoids from Brucea antidysenterica.
作者信息
Imamura K, Fukamiya N, Okano M, Tagahara K, Lee K H
机构信息
Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
出版信息
J Nat Prod. 1993 Dec;56(12):2091-7. doi: 10.1021/np50102a010.
PMID:8133299
Abstract
Three new quassinoids, bruceanols D [1], E [2], and F [3], were isolated from Brucea antidysenterica, and their structures were elucidated by spectral evidence and chemical transformation. All of these compounds exhibited cytotoxicity against five human tumor cell lines, malignant melanoma (RPMI-7951), lung carcinoma (A-549), ileocecal adenocarcinoma (HCT-8), epidermoid carcinoma of the nasopharynx (KB), and medulloblastoma (TE-671), and against murine lymphocytic leukemia (P-388).
摘要
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