硫链丝菌素与对硫链丝菌素敏感和耐药的枯草芽孢杆菌菌株核糖体的结合。
Binding of thiostrepton to ribosomes from thiostrepton-sensitive and -resistant Bacillus subtilis strains.
作者信息
Vince R, Weiss D, Gordon J, Howard G, Smith I, Pestka S
出版信息
Antimicrob Agents Chemother. 1976 Apr;9(4):665-7. doi: 10.1128/AAC.9.4.665.
Abstract
Binding of [(35)S]thiostrepton to ribosomes from thiostrepton-sensitive and -resistant strains of Bacillus subtilis was studied. Ribosomes from thiostrepton-resistant strains bound relatively little thiostrepton compared with ribosomes from thiostrepton-sensitive B. subtilis. In addition, ribosomes from revertant strains that were obtained as thiostrepton-sensitive revertants from thiostrepton-resistant strains bound [(35)S]thiostrepton similarly to ribosomes from the sensitive parental strain.
摘要
研究了[(35)S]硫链丝菌素与枯草芽孢杆菌硫链丝菌素敏感和抗性菌株核糖体的结合情况。与硫链丝菌素敏感的枯草芽孢杆菌核糖体相比，硫链丝菌素抗性菌株的核糖体结合的硫链丝菌素相对较少。此外，从硫链丝菌素抗性菌株获得的硫链丝菌素敏感回复突变株的核糖体与敏感亲本菌株的核糖体类似地结合[(35)S]硫链丝菌素。
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引用本文的文献
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Thiostrepton-resistant mutants of Bacillus subtilis: localization of resistance to the 50S subunit.枯草芽孢杆菌硫链丝菌素抗性突变体：对50S亚基抗性的定位
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2
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Proc Natl Acad Sci U S A. 1978 Dec;75(12):5993-7. doi: 10.1073/pnas.75.12.5993.
本文引用的文献
1
Modes of action of erythromycin and thiostrepton as inhibitors of protein synthesis.红霉素和硫链丝菌素作为蛋白质合成抑制剂的作用模式。
FEBS Lett. 1971 Oct 15;18(1):1-5. doi: 10.1016/0014-5793(71)80392-7.
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Inhibition by thiostrepton of the formation of a ribosome-bound guanine nucleotide complex.硫链丝菌素对核糖体结合鸟嘌呤核苷酸复合物形成的抑制作用。
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Studies on translocation. VI. Thiostrepton prevents the formation of a ribosome-G factor-guanine nucleotide complex.易位研究。VI. 硫链丝菌素可阻止核糖体 - G因子 - 鸟嘌呤核苷酸复合物的形成。
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The mode of action of thiostreption in vivo.硫链丝菌素在体内的作用方式。
Biochem Biophys Res Commun. 1971 Aug 20;44(4):912-7. doi: 10.1016/0006-291x(71)90798-4.
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Thiostrepton, an inhibitor of 5OS ribosome subunit function.硫链丝菌素，一种50S核糖体亚基功能抑制剂。
J Bacteriol. 1970 Mar;101(3):1073-5. doi: 10.1128/jb.101.3.1073-1075.1970.
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Inhibitors of ribosome functions.核糖体功能抑制剂。
Annu Rev Microbiol. 1971;25:487-562. doi: 10.1146/annurev.mi.25.100171.002415.
7
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Effect of siomycin on the acceptor site of Escherichia coli ribosomes.硫霉素对大肠杆菌核糖体受体位点的作用。
Biochem Biophys Res Commun. 1971 Nov 5;45(3):728-34. doi: 10.1016/0006-291x(71)90477-3.
9
Inhibition by thiopeptin of ribosomal functions associated with T and G factors.硫肽菌素对与T因子和G因子相关的核糖体功能的抑制作用。
Biochem Biophys Res Commun. 1971 Aug 20;44(4):859-63. doi: 10.1016/0006-291x(71)90790-x.
10
Effect of siomycin on protein synthesizing activity of Escherichia coli ribosomes.西奥霉素对大肠杆菌核糖体蛋白质合成活性的影响。
Biochem Biophys Res Commun. 1970;39(6):1189-93. doi: 10.1016/0006-291x(70)90686-8.
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