硫链丝菌素与对硫链丝菌素敏感和耐药的枯草芽孢杆菌菌株核糖体的结合。
Binding of thiostrepton to ribosomes from thiostrepton-sensitive and -resistant Bacillus subtilis strains.
作者信息
Vince R, Weiss D, Gordon J, Howard G, Smith I, Pestka S
出版信息
Antimicrob Agents Chemother. 1976 Apr;9(4):665-7. doi: 10.1128/AAC.9.4.665.
Abstract
Binding of [(35)S]thiostrepton to ribosomes from thiostrepton-sensitive and -resistant strains of Bacillus subtilis was studied. Ribosomes from thiostrepton-resistant strains bound relatively little thiostrepton compared with ribosomes from thiostrepton-sensitive B. subtilis. In addition, ribosomes from revertant strains that were obtained as thiostrepton-sensitive revertants from thiostrepton-resistant strains bound [(35)S]thiostrepton similarly to ribosomes from the sensitive parental strain.
摘要
研究了[(35)S]硫链丝菌素与枯草芽孢杆菌硫链丝菌素敏感和抗性菌株核糖体的结合情况。与硫链丝菌素敏感的枯草芽孢杆菌核糖体相比，硫链丝菌素抗性菌株的核糖体结合的硫链丝菌素相对较少。此外，从硫链丝菌素抗性菌株获得的硫链丝菌素敏感回复突变株的核糖体与敏感亲本菌株的核糖体类似地结合[(35)S]硫链丝菌素。
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引用本文的文献
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Thiostrepton-resistant mutants of Bacillus subtilis: localization of resistance to the 50S subunit.
Mol Gen Genet. 1976 Mar 30;144(3):235-41. doi: 10.1007/BF00341721.
2
Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA.
Proc Natl Acad Sci U S A. 1978 Dec;75(12):5993-7. doi: 10.1073/pnas.75.12.5993.
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