Stadler P, Van Amstel S R, Van Rensburg I B, Williams M C
Departement Geneeskunde, Fakulteit Veeartsenykunde, Universiteit van Pretoria, Onderstepoort, Republick van Suid-Afrika.
J S Afr Vet Assoc. 1993 Dec;64(4):172-7.
Five Holstein Friesian calves varying in age from 7 to 9 weeks old, were suspected of suffering from an inherited granulocytopathy known as bovine leucocyte adhesion deficiency (BLAD). Four of them were examined clinically and at necropsy. The most significant clinical findings were fever, depression, weakness, emaciation, diarrhoea, pseudomembranous gingivitis, loose teeth, respiratory infection and occult blood in the faeces. Significant clinicopathological findings were marked leucocytosis, mainly due to a neutrophilia, hypoalbuminemia, hypogammaglobulinemia, increased alpha- and beta-globulins, elevated alkaline phosphatase enzyme activity, hypoglycaemia, and decreased blood urea concentrations. The necropsy revealed emaciated carcasses, granulomatous to necrotising gingivitis, pseudomembranous to necrotising enteritis with perforations, bronchopneumonia, splenic atrophy, and hypoplasia of the thymus. Histopathological examination supported the macroscopic findings.
5头年龄在7至9周的荷斯坦弗里生犊牛被怀疑患有一种遗传性粒细胞病，即牛白细胞黏附缺陷症（BLAD）。其中4头接受了临床检查和尸检。最显著的临床症状为发热、抑郁、虚弱、消瘦、腹泻、假膜性牙龈炎、牙齿松动、呼吸道感染以及粪便潜血。显著的临床病理表现为明显的白细胞增多，主要是中性粒细胞增多、低白蛋白血症、低球蛋白血症、α和β球蛋白增加、碱性磷酸酶活性升高、低血糖以及血尿素浓度降低。尸检显示尸体消瘦、肉芽肿性至坏死性牙龈炎、假膜性至坏死性肠炎伴穿孔、支气管肺炎、脾脏萎缩以及胸腺发育不全。组织病理学检查支持了大体检查结果。
