Agerholm J S, Houe H, Jørgensen C B, Basse A
Department of Pathology and Epidemiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Acta Vet Scand. 1993;34(3):237-43. doi: 10.1186/BF03548187.
The patho-anatomical findings in 3 Danish Holstein-Friesian calves affected with bovine leukocyte adhesion deficiency (BLAD) are described. The diagnosis was confirmed by genotyping for the BLAD mutagene by polymerase chain reaction technique. The main clinical symptoms were general unthriftyness and leukocytosis with a high proportion of neutrophils. None of the calves suffered from severe infections and the major pathological changes were different from those described in previously published cases. One calf had a fibro-granulomatous perilienitis and calcification of splenic stroma and pulmonic arteries. In the other cases only minor pathological changes were present.
描述了3头患有牛白细胞粘附缺陷症（BLAD）的丹麦荷斯坦 - 弗里生犊牛的病理解剖学发现。通过聚合酶链反应技术对BLAD突变基因进行基因分型，确诊了该疾病。主要临床症状为整体发育不良和白细胞增多，其中中性粒细胞比例较高。这些犊牛均未遭受严重感染，主要病理变化与先前发表病例中描述的不同。一头犊牛患有纤维肉芽肿性肝周炎以及脾间质和肺动脉钙化。在其他病例中，仅存在轻微的病理变化。
