成年小鼠脑中钙结合蛋白D28K mRNA的细胞分布
Cellular distribution of calbindin D28K mRNAs in the adult mouse brain.
作者信息
Frantz G D, Tobin A J
机构信息
Department of Biology, University of California, Los Angeles 90024-1606.
出版信息
J Neurosci Res. 1994 Feb 15;37(3):287-302. doi: 10.1002/jnr.490370302.
We have determined the cellular distribution of calbindin D28K mRNAs throughout the mouse brain by in situ hybridization. While these studies identified neuronal populations similar to those previously identified in rat brain by immunohistochemistry, some discrepancies exist. These may derive from species differences or from the immunological cross-reactivity of calbindin D28K antiserum with other proteins. We note an intriguing association between the distribution of neurons containing calbindin D28K mRNA and those reported by others to contain the inositol 1,4,5-triphosphate (InsP3) receptor.
我们通过原位杂交确定了钙结合蛋白D28K mRNA在整个小鼠大脑中的细胞分布。虽然这些研究鉴定出的神经元群体与先前在大鼠大脑中通过免疫组织化学鉴定出的相似，但仍存在一些差异。这些差异可能源于物种差异，也可能源于钙结合蛋白D28K抗血清与其他蛋白质的免疫交叉反应。我们注意到，含有钙结合蛋白D28K mRNA的神经元分布与其他人报道的含有肌醇1,4,5-三磷酸（InsP3）受体的神经元分布之间存在着有趣的关联。
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