Gilbert D, Margaritte C, Brard F, Tron F
Groupe de recherche en immunopathologie, CHU Charles-Nicolle, Rouen.
Rev Prat. 1994 Jan 1;44(1):57-61.
Systemic lupus erythematosus is a multifactorial, non organ-specific autoimmune disease. Studies of the disease in humans, of spontaneous murine models and of induced experimental models have made it possible to identify the various factors involved. These factors act on the immune system, the abnormalities of which include polyclonal B cell activation, selection of autoreactive B clones by autoantigen, and intervention of helper T cells. Other abnormalities, such as disturbance of the idiotypic network and alteration of suppressor T cell function, are not excluded.
系统性红斑狼疮是一种多因素的、非器官特异性自身免疫性疾病。对人类该疾病、自发性小鼠模型及诱导性实验模型的研究，已使识别其中涉及的各种因素成为可能。这些因素作用于免疫系统，其异常包括多克隆B细胞活化、自身抗原对自身反应性B克隆的选择以及辅助性T细胞的干预。其他异常，如独特型网络的紊乱和抑制性T细胞功能的改变，也不能排除。
