Turrigiano G, Abbott L F, Marder E
Department of Biology, Brandeis University, Waltham, MA 02254.
Science. 1994 May 13;264(5161):974-7. doi: 10.1126/science.8178157.
Learning and memory arise through activity-dependent modifications of neural circuits. Although the activity dependence of synaptic efficacy has been studied extensively, less is known about how activity shapes the intrinsic electrical properties of neurons. Lobster stomatogastric ganglion neurons fire in bursts when receiving synaptic and modulatory input but fire tonically when pharmacologically isolated. Long-term isolation in culture changed their intrinsic activity from tonic firing to burst firing. Rhythmic stimulation reversed this transition through a mechanism that was mediated by a rise in intracellular calcium concentration. These data suggest that neurons regulate their conductances to maintain stable activity patterns and that the intrinsic properties of a neuron depend on its recent history of activation.
学习和记忆是通过神经回路的活动依赖性修饰产生的。尽管突触效能的活动依赖性已得到广泛研究，但对于活动如何塑造神经元的内在电特性却知之甚少。龙虾口胃神经节神经元在接受突触和调制输入时会爆发式放电，但在药理学分离时会持续放电。在培养中长期分离会将它们的内在活动从持续放电转变为爆发式放电。节律性刺激通过细胞内钙浓度升高介导的机制逆转了这种转变。这些数据表明，神经元调节其电导以维持稳定的活动模式，并且神经元的内在特性取决于其最近的激活历史。
