Tsai C H, Lu C S, Hua M S, Lo W L, Lo S K
Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Acta Neurol Scand. 1994 Jan;89(1):9-14.
Cognitive functions of 24 patients with early onset parkinsonism (age of onset before 40 years) and 24 controls were investigated by a battery of neuropsychological tests. Patients were shown to be impaired in performance IQ (PIQ), conceptual ability and regulation behavior, memory, visuospatial perception, and manual dexterity. Patients were also shown to have a higher Zung Depression score. However, analysis of the testing scores appeared to indicate that only a small portion of poor performance on neuropsychological tests are depression related. The results demonstrated that patients with early onset parkinsonism, in whom the factor of aging is not as important, still show cognitive dysfunction and suggested that Parkinson's disease itself can cause cognitive impairment.
通过一系列神经心理学测试，对24例早发性帕金森病患者（发病年龄在40岁之前）和24名对照者的认知功能进行了研究。结果显示，患者在操作智商（PIQ）、概念能力和调节行为、记忆、视觉空间感知及手部灵活性方面存在损害。患者的zung抑郁评分也较高。然而，对测试分数的分析似乎表明，神经心理学测试中表现不佳的情况只有一小部分与抑郁有关。结果表明，在早发性帕金森病患者中，衰老因素并非那么重要，但他们仍表现出认知功能障碍，这表明帕金森病本身可导致认知损害。
