化学物质在小鼠精子和精细胞中诱导产生的基因损伤在卵细胞中得以修复。
Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.
作者信息
Generoso W M, Cain K T, Krishna M, Huff S W
出版信息
Proc Natl Acad Sci U S A. 1979 Jan;76(1):435-7. doi: 10.1073/pnas.76.1.435.
Abstract
Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine, and benzo[a]pyrene treatments; and no difference was found for x-ray treatment.
摘要
通过对化学处理的精子和精细胞进行显性致死研究以及对第一次卵裂中期进行细胞学分析，获得了确凿证据，证明小鼠卵子能够修复雄性基因组中存在的遗传损伤。在对甲磺酸异丙酯处理的雌性品系之间发现的修复能力最大差异很大；对甲磺酸乙酯、三亚乙基蜜胺和苯并[a]芘处理的差异要小得多；而对X射线处理未发现差异。
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