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化学物质在小鼠精子和精细胞中诱导产生的基因损伤在卵细胞中得以修复。

Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.

作者信息

Generoso W M, Cain K T, Krishna M, Huff S W

出版信息

Proc Natl Acad Sci U S A. 1979 Jan;76(1):435-7. doi: 10.1073/pnas.76.1.435.

DOI:10.1073/pnas.76.1.435
PMID:284360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC382954/
Abstract

Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine, and benzo[a]pyrene treatments; and no difference was found for x-ray treatment.

摘要

通过对化学处理的精子和精细胞进行显性致死研究以及对第一次卵裂中期进行细胞学分析，获得了确凿证据，证明小鼠卵子能够修复雄性基因组中存在的遗传损伤。在对甲磺酸异丙酯处理的雌性品系之间发现的修复能力最大差异很大；对甲磺酸乙酯、三亚乙基蜜胺和苯并[a]芘处理的差异要小得多；而对X射线处理未发现差异。

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Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.化学物质在小鼠精子和精细胞中诱导产生的基因损伤在卵细胞中得以修复。
Proc Natl Acad Sci U S A. 1979 Jan;76(1):435-7. doi: 10.1073/pnas.76.1.435.
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本文引用的文献

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EMBRYONIC LETHALITY OF VARIOUS MOUSE STRAINS AS A CONSEQUENCE OF X-IRRADIATION-INDUCED INJURIES OF THE FATHER'S SPERMATOZOA.X射线诱导的父本精子损伤导致的各种小鼠品系胚胎致死性
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Radiation dose rate and mutation frequency.辐射剂量率与突变频率。
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Strain and sex variations in the sensitivity of mice to dominant-lethal induction with ethyl methanesulfonate.小鼠对甲磺酸乙酯显性致死诱导敏感性的品系和性别差异。
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Chemically induced dominant-lethal mutations and cell killing mouse oocytes in the advanced stages of follicular development.化学诱导的显性致死突变和细胞杀伤处于卵泡发育晚期的小鼠卵母细胞。
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Changing levels of uv light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation.减数分裂成熟过程中小鼠卵母细胞中紫外线水平的变化及致癌物诱导的非预定DNA合成
Exp Cell Res. 1978 Mar 1;112(1):121-5. doi: 10.1016/0014-4827(78)90532-3.