Luine V, Villegas M, Martinez C, McEwen B S
Department of Psychology, Hunter College, New York, NY 10021.
Brain Res. 1994 Mar 7;639(1):167-70. doi: 10.1016/0006-8993(94)91778-7.
Restraint stress, 6 h/day for 21 days, caused an impairment, during acquisition, of the performance of a spatial memory task, the eight-arm radial maze. The impairment was reversible, temporally limited and blocked by phenytoin, a blocker of excitatory amino acid action, or tianeptine, an antidepressant, which lowers extracellular serotonin. These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.
每天6小时、持续21天的束缚应激，在空间记忆任务（八臂放射状迷宫）的习得过程中导致了行为表现受损。这种损伤是可逆的、有时间限制的，并且可被苯妥英（一种兴奋性氨基酸作用的阻断剂）或噻奈普汀（一种降低细胞外5-羟色胺的抗抑郁药）所阻断。这些对行为的影响与应激诱导的海马CA3神经元树突可逆性萎缩相平行，而这种萎缩也可被这些药物阻断。
