Fisk J D, Pontefract A, Ritvo P G, Archibald C J, Murray T J
Department of Psychology, Camp Hill Medical Centre, Halifax, Nova Scotia, Canada.
Can J Neurol Sci. 1994 Feb;21(1):9-14.
Although fatigue is recognized as a symptom of MS, there have been insufficient methods for evaluating this symptom. We administered the Fatigue Impact Scale to 85 MS patients and 20 hypertensive patients. Neurologic impairment, mental health, and general health status were also assessed. MS patients reported significantly higher fatigue impact than hypertensive patients. Most MS patients reported fatigue as either their worst (14%), or one of their worst (55%) symptoms. Disease classification and neurologic impairment had little bearing on Fatigue Impact Scale scores in the MS sample. The best predictive models for mental health and general health status in the MS sample both included the Fatigue Impact Scale as a significant factor. This study demonstrates that: 1) fatigue is a very prevalent and severe problem in MS, 2) fatigue impact cannot be predicted by clinical measures of neurologic impairment, 3) fatigue has a significant effect on the mental health and general health status of MS patients.
尽管疲劳被认为是多发性硬化症（MS）的一种症状，但评估该症状的方法一直不足。我们对85例MS患者和20例高血压患者进行了疲劳影响量表测试。还评估了神经功能损害、心理健康和总体健康状况。MS患者报告的疲劳影响明显高于高血压患者。大多数MS患者称疲劳是他们最严重的症状（14%）或最严重的症状之一（55%）。在MS样本中，疾病分类和神经功能损害对疲劳影响量表得分影响不大。MS样本中预测心理健康和总体健康状况的最佳模型均将疲劳影响量表作为一个重要因素。本研究表明：1）疲劳在MS中是一个非常普遍且严重的问题；2）神经功能损害的临床指标无法预测疲劳影响；3）疲劳对MS患者的心理健康和总体健康状况有显著影响。
