Gong Y, Frenkel G D
Department of Biological Sciences, Rutgers University, Newark, NJ 07102.
Cancer Lett. 1994 Apr 1;78(1-3):195-9. doi: 10.1016/0304-3835(94)90051-5.
Pre-exposure of HeLa or NIH:OVCAR-3 cells to selenite resulted in a dose-dependent decrease in the ability of the cells to invade a layer of Matrigel, a reconstituted basement membrane preparation. In contrast, selenate, selenomethionine and sulfite had no significant effect on cell invasiveness. Exposure of HeLa cells to selenite also resulted in a decrease in two of the necessary steps of the invasion process, attachment and mobility; in contrast, exposure of OVCAR cells decreased attachment but not mobility. There was an apparent correlation between the processes that are affected by selenite and those that involve the cellular fibronectin receptor (alpha 5 beta 1 integrin).
将HeLa或NIH:OVCAR - 3细胞预先暴露于亚硒酸盐会导致细胞侵袭基质胶（一种重组基底膜制剂）层的能力呈剂量依赖性下降。相比之下，硒酸盐、硒代蛋氨酸和亚硫酸盐对细胞侵袭性没有显著影响。将HeLa细胞暴露于亚硒酸盐还会导致侵袭过程中两个必要步骤，即黏附和迁移能力下降；相比之下，将OVCAR细胞暴露于亚硒酸盐会降低黏附能力，但不会降低迁移能力。亚硒酸盐所影响的过程与那些涉及细胞纤连蛋白受体（α5β1整合素）的过程之间存在明显的相关性。
