Yu X, Raoult D
Unité des Rickettsies, Faculté de Medécine, CNRS EP J 0054, Marseille, France.
FEMS Microbiol Lett. 1994 Mar 15;117(1):15-9. doi: 10.1111/j.1574-6968.1994.tb06735.x.
Four mouse monoclonal antibodies reacting with Coxiella burnetti lipopolysaccharide antigens were produced and used in serotyping 17 C. burnetii isolates from acute Q fever and Q fever endocarditis patients in France. Two monoclonal antibodies (1B2 and 3B6) were considered specific for the Priscilla strain, a representative of Q fever endocarditis isolates, and did not react with the Nine Mile strain, which is representative of acute Q fever isolates. Monoclonal antibodies Nos. 1B2 and 3B6 reacted with 75% (3/4) acute Q fever isolates and 85% (11/13) of endocarditis isolates from France. It is reasonable to conclude that Priscilla-like strains cause both acute Q fever and Q fever endocarditis. The hypothesis that Priscilla-like strains only are associated with Q fever endocarditis should be reconsidered.
制备了四种与伯氏考克斯氏体脂多糖抗原发生反应的小鼠单克隆抗体，并将其用于对来自法国急性Q热和Q热心内膜炎患者的17株伯氏考克斯氏体分离株进行血清分型。两种单克隆抗体（1B2和3B6）被认为对普里西拉菌株具有特异性，该菌株是Q热心内膜炎分离株的代表，且不与九英里菌株发生反应，后者是急性Q热分离株的代表。单克隆抗体1B2和3B6与75%（3/4）的法国急性Q热分离株以及85%（11/13）的法国心内膜炎分离株发生反应。有理由得出结论，普里西拉样菌株可引起急性Q热和Q热心内膜炎。仅普里西拉样菌株与Q热心内膜炎相关的假说应重新考虑。
