Polubiec A, Jórasz I, Pietrzak J, Soszka A, Stepka K, Zaryn A
Dept. of Internal Medicine and Hematology, Medical Academy of Warsaw, Poland.
Infection. 1994 Jan-Feb;22(1):62-4. doi: 10.1007/BF01780772.
An open, randomized study was carried out to compare the efficacy of ciprofloxacin, 250 mg twice daily, and ofloxacin, 200 mg twice daily, in hospitalized patients with lower respiratory tract infections such as bacterial exacerbation of chronic bronchitis or community-acquired pneumonia. Fifty patients were treated in each group. The duration of treatment was 10 to 12 days. Microbiological examinations were carried out on sputum samples taken before, during and after treatment. In both groups, the clinical results were considered to be excellent, with clinical cure in 98% of the patients treated with ciprofloxacin and in 90% of patients treated with ofloxacin. Eradication of the initial sputum isolate was achieved in 98% of the patients of the ciprofloxacin group and in 82% of the patients of the ofloxacin group.
一项开放性随机研究开展，以比较每日两次服用250毫克环丙沙星和每日两次服用200毫克氧氟沙星，对患有下呼吸道感染（如慢性支气管炎细菌感染加重或社区获得性肺炎）的住院患者的疗效。每组治疗50名患者。治疗持续时间为10至12天。在治疗前、治疗期间和治疗后采集的痰液样本上进行微生物学检查。两组的临床结果均被认为极佳，环丙沙星治疗的患者中98%临床治愈，氧氟沙星治疗的患者中90%临床治愈。环丙沙星组98%的患者初始痰液分离菌被清除，氧氟沙星组82%的患者初始痰液分离菌被清除。
