经皮应用2,4-二硝基氯苯后麻风病损中CD1阳性表皮朗格汉斯细胞数量减少。
Reduction in CD1 positive epidermal Langerhans cell numbers in leprosy lesions following epicutaneous application of 2:4 dinitrochlorobenzene.
作者信息
Narayanan R B, Natarajan M, Bagga A K, Katoch K
机构信息
Central JALMA Institute for Leprosy (ICMR), Agra.
出版信息
Indian J Lepr. 1993 Oct-Dec;65(4):423-7.
PMID:8182289
Abstract
A study was made on Langerhans cells (LC) in the dermal lesions of leprosy after epicutaneous application of 2:4 dinitrochlorobenzene (DNCB) to the lesion. LC were quantitated with OKT6 monoclonal antibody and indirect immunofluorescence. A depletion or reduction in the numbers of CD1+ epidermal LC was observed at both 4 and 24 hours after the application of DNCB in the lesions of both tuberculoid and lepromatous leprosy, compared to untreated lesions.
摘要
对麻风病皮肤损害处经皮涂抹2,4-二硝基氯苯（DNCB）后的朗格汉斯细胞（LC）进行了一项研究。用OKT6单克隆抗体和间接免疫荧光法定量LC。与未处理的损害相比，在结核样型和瘤型麻风病损害处涂抹DNCB后4小时和24小时均观察到CD1⁺表皮LC数量的减少或降低。
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