Nazaimoon W M, Ng M L, Osman A, Tan T T, Wu L L, Khalid B A
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur.
Med J Malaysia. 1993 Sep;48(3):297-302.
Fasting growth hormone (GH) level is an important reference level in dynamic tests of GH secretion. Other studies have demonstrated sex and age variation in the rate of GH secretion. We analysed fasting serum samples from 377 normal subjects (193 males and 184 females, age range 6 to 81 years old), using our in-house enzyme immunoassay. We found sex differences in fasting GH levels to be only significant in the prepubertal children (Tanner stage I), being higher in girls than in age-matched boys (p < 0.05). Both sexes showed age-dependent changes in fasting GH levels (p < 0.001); highest levels were achieved at puberty and subsequently declined with advancing age. Hence, the physiological sex difference and age-dependency in GH secretion can also be demonstrated in single fasting samples.
空腹生长激素（GH）水平是生长激素分泌动态试验中的一个重要参考水平。其他研究已证实生长激素分泌速率存在性别和年龄差异。我们使用自行研发的酶免疫测定法，分析了377名正常受试者（193名男性和184名女性，年龄范围为6至81岁）的空腹血清样本。我们发现，空腹GH水平的性别差异仅在青春期前儿童（坦纳I期）中显著，女孩高于年龄匹配的男孩（p < 0.05）。两性的空腹GH水平均呈现出年龄依赖性变化（p < 0.001）；青春期时达到最高水平，随后随年龄增长而下降。因此，生长激素分泌的生理性性别差异和年龄依赖性也可以在单次空腹样本中得到证实。
