Carbone M, Pass H I, Rizzo P, Marinetti M, Di Muzio M, Mew D J, Levine A S, Procopio A
Section on DNA Replication, Repair, and Mutagenesis, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
Oncogene. 1994 Jun;9(6):1781-90.
Mesotheliomas are pleural, pericardial, or peritoneal neoplasms frequently associated with asbestos exposure, and it is estimated that over the next twenty years up to 80,000 new cases are expected in the USA alone. We found simian virus 40-like DNA sequences in 29 of 48 mesotheliomas studied (60%) and demonstrated simian virus large-T antigen expression in 13 of 16 specimens. The matching lung samples did not contain simian virus 40-like sequences; however, they contained asbestos. These findings are to our knowledge the first demonstration of a physical link between DNA virus-like sequences and human mesothelioma. We suggest that a simian virus 40-like virus may act independently or as a co-carcinogen with asbestos. Moreover, the selective large T antigen expression by mesothelioma and not by the surrounding pulmonary parenchyma may have both diagnostic and therapeutic implications.
间皮瘤是常与接触石棉相关的胸膜、心包或腹膜肿瘤，据估计，仅在美国，未来二十年内预计将出现多达80000例新病例。我们在所研究的48例间皮瘤中的29例（60%）中发现了猿猴病毒40样DNA序列，并在16个标本中的13个中证实了猿猴病毒大T抗原的表达。匹配的肺样本中不包含猿猴病毒40样序列；然而，它们含有石棉。据我们所知，这些发现首次证明了DNA病毒样序列与人类间皮瘤之间存在物理联系。我们认为，一种猿猴病毒40样病毒可能独立起作用，或作为石棉的协同致癌物起作用。此外，间皮瘤而非周围肺实质选择性表达大T抗原可能具有诊断和治疗意义。
