Takahashi H, Miyoshi T, Boki K
Department of Public Health, School of Medicine, University of Tokushima, Japan.
Tokushima J Exp Med. 1993 Dec;40(3-4):159-67.
A basic study on hydrophilicity of gelatin was made of the fitness, water-absorbing ability, water-holding ability, affinity and stability of included water in order to utilize it as a protective covering for medical use. Gelatin No. 3, being highly viscous and having a lower jelly strength, was strongly viscous and flexible, and thus, it stuck close to the surface of a lesioned site such as a wound or a burn. Since the melting point of a gelatin containing 50% water was in the range of 43 to 45 degrees C, the gelatin will be fully used as a protective covering for a wound. Below 20% relative humidity, water molecules were bound to the polar amino acid side chains of gelatin and the bound water caused a swelling of the gelatin, which is maintained by capillary sorption of water into its collagen-like four-dimensional structure. The amount of water sorbed at a relative humidity of 80% at 11 degrees C was higher by 50 to 80 mg/g compared to that at 37 degrees C. Gelatin No. 3 had a very high water-holding ability and it was very hard for it to release the sorbed water at a relative humidity of 80 to 90%. Water molecules were bound to the strong active sites of the gelatin at low relative humidity. The gelatin swelled and then, newly active sites appeared on the surface of the gelatin. The hydrophilic activity decreased with an increase in moisture content, whereas the stability of water molecules in the gelatin increased.(ABSTRACT TRUNCATED AT 250 WORDS)
为了将明胶用作医用保护涂层，对其亲水性进行了一项基础研究，涉及适用性、吸水能力、保水能力、亲和力以及所含水分的稳定性。3号明胶粘性高、凝胶强度低，粘性强且有柔韧性，因此能紧密贴合伤口或烧伤等损伤部位的表面。由于含水量为50%的明胶熔点在43至45摄氏度范围内，这种明胶将可充分用作伤口的保护涂层。在相对湿度低于20%时，水分子与明胶的极性氨基酸侧链结合，结合水使明胶膨胀，这通过水的毛细管吸附作用维持在其类胶原的四维结构中。在11摄氏度、相对湿度80%时吸附的水量比在37摄氏度时高50至80毫克/克。3号明胶保水能力非常高，在相对湿度80%至90%时很难释放所吸附的水。在低相对湿度下，水分子与明胶的强活性位点结合。明胶膨胀，然后其表面出现新的活性位点。亲水性活性随含水量增加而降低，而明胶中水分子的稳定性增加。（摘要截短于250字）
