Department of Applied Chemistry, School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, Guangdong, China.
Agricultural Product Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524001, Guangdong, China.
Mar Drugs. 2018 Aug 4;16(8):273. doi: 10.3390/md16080273.
Effective hemostasis is vital to reduce the pain and mortality of patients, and the research and development of hemostatic materials are prerequisite for effective hemostasis. Chitosan (CS), with good biodegradability, biocompatibility and non-toxicity, has been widely applied in bio-medicine, the chemical industry, the food industry and cosmetics. The excellent hemostatic properties of CS have been extensively studied. As a result, chitosan-based composite hemostatic materials have been emerging. In this review, the hemostatic mechanism of chitosan is briefly discussed, and then the progress of research on chitosan-based composite hemostatic materials with multiple forms such as films, sponges, hydrogels, particles and fibers are introduced. Finally, future perspectives of chitosan-based composite hemostatic materials are given. The objective of this review is to provide a reference for further research and development of effective hemostatic materials.
有效止血对于减轻患者的疼痛和死亡率至关重要，而止血材料的研究和开发是实现有效止血的前提。壳聚糖（CS）具有良好的生物降解性、生物相容性和无毒，已广泛应用于生物医学、化学工业、食品工业和化妆品。CS 的优异止血性能已得到广泛研究。因此，壳聚糖基复合止血材料不断涌现。在本文中，简要讨论了壳聚糖的止血机制，然后介绍了具有多种形式（如膜、海绵、水凝胶、颗粒和纤维）的壳聚糖基复合止血材料的研究进展。最后，给出了壳聚糖基复合止血材料的未来展望。本文的目的是为有效止血材料的进一步研究和开发提供参考。
