Sergeenko N I, Kichigina T N, Nekrasov V B, Sabgir M S
Anesteziol Reanimatol. 1993 Nov-Dec(6):8-11.
The study was performed on 94 urological patients, aged 15 to 78 years, subjected to planned operations. The initial autonomic tone, autonomic reactivity, autonomic maintenance of the activity, ACTH and cortisol content have been investigated in the ward and in the operation room with concomitant premedication with pipolphen in combination with promedol and diazepam in combination with promedol. Tactile and pain thresholds were studied in patients on premedication in the ward and the operation room. It has been noted that positive effect of premedication, an increase in the pain threshold and adequate neuroautonomic protection do not only depend on the presence or absence of diazepam in premedication, but also on the initial autonomic tone, autonomic reactivity, and autonomic maintenance of the activity. The above parameters in their turn depend on the functional state of the autonomic nervous system, the patient's age, concomitant diseases, and other factors determining general physical status of the patient.
该研究对94名年龄在15至78岁之间、计划接受手术的泌尿外科患者进行。在病房和手术室对患者的初始自主神经张力、自主神经反应性、活动的自主神经维持、促肾上腺皮质激素（ACTH）和皮质醇含量进行了研究，同时给予哌泊酚联合异丙嗪以及地西泮联合异丙嗪进行术前用药。在病房和手术室对接受术前用药的患者进行了触觉和疼痛阈值研究。已经注意到，术前用药的积极效果、疼痛阈值的提高以及充分的神经自主保护不仅取决于术前用药中是否存在地西泮，还取决于初始自主神经张力、自主神经反应性以及活动的自主神经维持。而上述参数又取决于自主神经系统的功能状态、患者年龄、伴随疾病以及其他决定患者总体身体状况的因素。
