Pimpinelli S, Pignone D, Gatti M, Olivieri G
Mutat Res. 1976 Apr;35(1):101-10. doi: 10.1016/0027-5107(76)90172-x.
The relative frequencies of X-ray-induced symmetrical and asymmetrical chromatid interchanges were analysed as a function of the cell cycle in somatic cells of Drosophila melanogaster. In exchanges between autosomes, during the S phase, a clear prevalence of asymmetrical rejoining was observed. Later, this prevalence became reduced as the cell approached mitosis. On the other hand, in the exchanges between X-chromosomes in the females there were no significant variations in the type of rejoining through the cell cycle, there being a slight but consistent preference for symmetrical rejoining. These data are discussed in relation to the hypothesis proposed by Olivieri et al. [12] on the organization of the chromosomal sub-units in the interphase nucleus.
分析了X射线诱导的对称和不对称染色单体互换的相对频率，作为黑腹果蝇体细胞中细胞周期的函数。在常染色体之间的交换中，在S期观察到不对称重新连接明显占优势。后来，随着细胞接近有丝分裂，这种优势减弱。另一方面，在雌性X染色体之间的交换中，整个细胞周期内重新连接类型没有显著变化，对称重新连接有轻微但一致的偏好。根据Olivieri等人[12]提出的关于间期核中染色体亚单位组织的假说对这些数据进行了讨论。
