人类白细胞抗原（HLA）和T细胞受体β链DNA多态性可识别少关节型幼年类风湿关节炎患者的一个独特亚组。
HLA and T cell receptor beta-chain DNA polymorphisms identify a distinct subset of patients with pauciarticular-onset juvenile rheumatoid arthritis.
作者信息
Charmley P, Nepom B S, Concannon P
机构信息
Virginia Mason Research Center, Seattle, Washington 98101.
出版信息
Arthritis Rheum. 1994 May;37(5):695-701. doi: 10.1002/art.1780370513.
OBJECTIVE
To evaluate and extend upon a reported association of a T cell receptor (TCR) V beta coding region polymorphism with pauciarticular-onset juvenile rheumatoid arthritis (JRA).
METHODS
TCR V beta 6.1 genotypes and haplotypes in JRA and control groups were determined by DNA amplification.
RESULTS
Haplotypes of the V beta 6.1 gene which encode a nonfunctional form of V beta 6.1 were significantly associated with pauciarticular JRA in patients possessing the HLA-DQA1*0101 allele (P = 0.0073).
CONCLUSION
A TCR V beta gene segment in the vicinity of V beta 6.1, possibly V beta 6.1, is apparently involved in the pathogenesis of pauciarticular-onset JRA in DQA1*0101-positive individuals.
目的
评估并拓展已报道的T细胞受体（TCR）Vβ编码区多态性与少关节型幼年类风湿性关节炎（JRA）的关联。
方法
通过DNA扩增确定JRA组和对照组的TCR Vβ6.1基因型和单倍型。
结果
编码无功能形式Vβ6.1的Vβ6.1基因单倍型与携带HLA - DQA1*0101等位基因的少关节型JRA患者显著相关（P = 0.0073）。
结论
Vβ6.1附近的一个TCR Vβ基因片段，可能是Vβ6.1，显然参与了DQA1*0101阳性个体少关节型JRA的发病机制。
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