无功能等位基因TCRBV6S1B与幽门螺杆菌感染密切相关。
The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection.
作者信息
Kunstmann E, Hardt C, Elitok E, Harder M, Suerbaum S, Peitz U, Schmiegel W, Epplen J T
机构信息
Department of Molecular Human Genetics, Ruhr-University, 44780 Bochum, Germany.
出版信息
Infect Immun. 2000 Nov;68(11):6493-5. doi: 10.1128/IAI.68.11.6493-6495.2000.
Abstract
To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected individuals (controls). H. pylori infection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; chi(2) = 13; P = 0.00032; P value corrected for multiple comparisons [Bonferroni correction] = 0. 00063).
摘要
为了确定幽门螺杆菌感染的遗传易感性因素，对203名幽门螺杆菌感染个体和180名未感染个体（对照组）的多态性T细胞受体基因元件进行了研究。幽门螺杆菌感染与非功能性TCRBV6S1B元件纯合个体高度相关（优势比=5.9；卡方=13；P=0.00032；经多重比较校正后的P值[Bonferroni校正]=0.00063）。
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