MacMillan H, Steiner M
McMaster Psychiatric Unit, St. Joseph's Hospital, Hamilton, Ontario, Canada.
Biol Psychiatry. 1994 Feb 15;35(4):272-7. doi: 10.1016/0006-3223(94)91258-0.
Atrial natriuretic factor (ANF) is the first of a group of atrial natriuretic peptides (ANPs) discovered since 1981. This group of peptides is thought to have an important role in sodium homeostasis and regulation of fluid volume. Although the role of ANF in cardiovascular and renal disorders is under investigation, the specific signaling involvement that ANF may have in the central nervous system is still unexplored. To date, ANF has not as yet been associated with a given functional area in the brain, nor has it been shown to be linked to any particular psychopathology. Neuropharmacology research of these peptides and their drug manipulation is needed to advance our knowledge of the possible role of ANF in psychiatry beyond the current level of speculation.
心房利钠因子（ANF）是自1981年以来发现的一组心房利钠肽（ANP）中的首个成员。这组肽被认为在钠稳态和体液容量调节中起重要作用。尽管ANF在心血管和肾脏疾病中的作用正在研究中，但其在中枢神经系统中可能涉及的具体信号传导仍未被探索。迄今为止，ANF尚未与大脑中的特定功能区域相关联，也未显示与任何特定的精神病理学有关。需要对这些肽及其药物操纵进行神经药理学研究，以将我们对ANF在精神病学中可能作用的认识推进到超出当前推测水平。
