Masotto C, Negro-Vilar A
Brain Res Bull. 1985 Nov;15(5):523-6. doi: 10.1016/0361-9230(85)90044-9.
A family of peptides, known as atrial natriuretic factors (ANF), have been isolated from atrial muscle tissue and reported to have profound effects on water and salt metabolism. ANF have also been reported to be present in the brain. The primary actions of these peptides lead to a reduction in plasma and extracellular fluid volume by eliciting natriuresis and diuresis, and by opposing the action of other peptidergic systems such as the vasopressin and angiotensin systems that promote water retention and enhance drinking behavior. This study was designed to determine if, in addition to its peripheral actions, ANF would also affect water ingestion, a mechanism that would be consistent with its general actions as a factor regulating extracellular fluid volume. Intraventricular (IVT) administration of an ANF, atriopeptin III (APIII), to intact male rats resulted in a significant inhibition of water intake in animals which were conditioned to drink during a one hour period. The inhibitory effects of APIII were immediate and most effective during the first 15 minute period, when maximal drinking occurred. Most remarkably, APIII given IVT also inhibited the potent dipsogenic action of angiotensin II (AII) on both water and a 2% NaCl solution intake. The results strongly suggest that ANF may have a significant role in central regulation of fluid intake and that its antidipsogenic effects may be mediated, at least in part, by an inhibitory effect on the central action of AII.
一类被称为心房利钠因子（ANF）的肽已从心房肌组织中分离出来，并据报道对水盐代谢有深远影响。据报道，ANF在大脑中也有存在。这些肽的主要作用是通过引起利钠和利尿，并通过对抗其他肽能系统（如促进水潴留和增强饮水行为的血管加压素和血管紧张素系统）的作用，从而减少血浆和细胞外液量。本研究旨在确定除了其外周作用外，ANF是否还会影响水的摄入，这一机制与其作为调节细胞外液量的因子的一般作用是一致的。向完整的雄性大鼠脑室内（IVT）注射一种ANF，即心房肽III（APIII），导致在一小时内有饮水习惯的动物的饮水量显著受到抑制。APIII的抑制作用是即时的，并且在最初的15分钟内最为有效，此时饮水量最大。最显著的是，经IVT给予的APIII还抑制了血管紧张素II（AII）对水和2%氯化钠溶液摄入的强烈致渴作用。结果强烈表明，ANF可能在液体摄入的中枢调节中起重要作用，并且其抗渴作用可能至少部分是通过对AII中枢作用的抑制作用介导的。
