Radhakrishnan K, Litchy W J, O'Fallon W M, Kurland L T
Department of Neurology, Mayo Clinic, Rochester, MN 55905.
Brain. 1994 Apr;117 ( Pt 2):325-35. doi: 10.1093/brain/117.2.325.
An epidemiological survey of cervical radiculopathy in Rochester, Minnesota, 1976-90, through the records-linkage system of the Mayo Clinic ascertained 561 patients (332 males and 229 females). Ages ranged from 13 to 91 years; the mean age +/- SD was 47.6 +/- 13.1 years for males and 48.2 +/- 13.8 years for females. A history of physical exertion or trauma preceding the onset of symptoms occurred in only 14.8% of cases. A past history of lumbar radiculopathy was present in 41%. The median duration of symptoms prior to diagnosis was 15 days. A monoradiculopathy involving C7 nerve root was the most frequent, followed by C6. A confirmed disc protrusion was responsible for cervical radiculopathy in 21.9% of patients; 68.4% were related to spondylosis, disc or both. During the median duration of follow-up of 4.9 years, recurrence of the condition occurred in 31.7%, and 26% underwent surgery for cervical radiculopathy. A combination of radicular pain and sensory deficit, and objective muscle weakness were predictors of a decision to operate. At last follow-up 90% of our population-based patients were asymptomatic or only midly incapacitated due to cervical radiculopathy. The average annual age-adjusted incidence rates per 100,000 population for cervical radiculopathy in Rochester were 83.2 for the total, 107.3 for males and 63.5 for females. The age-specific annual incidence rate per 100,000 population reached a peak of 202.9 for the age group 50-54 years.
通过梅奥诊所的记录关联系统,对明尼苏达州罗切斯特市1976年至1990年期间的颈神经根病进行了一项流行病学调查,确定了561例患者(332例男性和229例女性)。年龄范围为13至91岁;男性的平均年龄±标准差为47.6±13.1岁,女性为48.2±13.8岁。仅有14.8%的病例在症状出现前有体力活动或创伤史。41%的患者有腰椎神经根病病史。诊断前症状的中位持续时间为15天。涉及C7神经根的单神经根病最为常见,其次是C6。21.9%的患者确诊的椎间盘突出是颈神经根病的原因;68.4%与脊柱病、椎间盘或两者有关。在中位随访期4.9年期间,31.7%的患者病情复发,26%的患者因颈神经根病接受了手术。神经根性疼痛和感觉障碍以及客观的肌肉无力是决定手术的预测因素。在最后一次随访时,我们基于人群的患者中有90%无症状或仅因颈神经根病而轻度丧失能力。罗切斯特市颈神经根病每10万人口的年龄调整后年发病率总体为83.2,男性为107.3,女性为63.5。每10万人口的年龄特异性年发病率在50 - 54岁年龄组达到峰值202.9。