Repo U K, Nieminen P
Scand J Respir Dis. 1976;57(1):1-4.
A 64-year-old asthmatic woman began to suffer from urinary irritation after 5 months' treatment with disodium cromoglycate. After 10 months she contracted, additionally, a dry, hacking cough and gradually increasing exercise-induced dyspnoea. Chest X-ray revealed scattered, micronodular infiltrations in both lungs, and her spirogram was clearly restrictive. Peripheral blood showed eosinophilia of 23.5%. Urine was clean. When DSCG was withdrawn, her urinary symptoms and cough disappeared overnight, and her dyspnoea improved within weeks, as did her chest X-ray. Inhalation provocation test with DSCG 2 months later resulted in an immediate asthmatic reaction followed by a possible delayed-type reaction 9 hours later. Disodium cromoglycate is regarded as the possible aetiologic agent.
一名64岁的哮喘女性在接受色甘酸钠治疗5个月后开始出现尿路刺激症状。10个月后，她又出现了干咳、阵咳，并逐渐出现运动性呼吸困难加重。胸部X线显示双肺散在微小结节浸润，肺功能检查显示明显的限制性通气障碍。外周血嗜酸性粒细胞增多至23.5%。尿液检查正常。停用色甘酸钠后，她的尿路症状和咳嗽在一夜之间消失，呼吸困难在数周内改善，胸部X线表现也有所改善。2个月后进行色甘酸钠吸入激发试验，立即出现哮喘反应，9小时后可能出现迟发型反应。色甘酸钠被认为是可能的病因。
