肌萎缩侧索硬化症患者与对照受试者骨骼肌中的铅浓度。
Lead concentration in skeletal muscle in amyotrophic lateral sclerosis patients and control subjects.
作者信息
Conradi S, Ronnevi L O, Vesterberg O
出版信息
J Neurol Neurosurg Psychiatry. 1978 Nov;41(11):1001-4. doi: 10.1136/jnnp.41.11.1001.
Abstract
The concentration of lead in the vastus lateralis muscle was determined in patients with amyotrophic lateral sclerosis and control subjects by flameless atomic absorption spectrophotometry. No statistically significant differences were found between these groups, and in both the figures were of the same magnitude as those earlier reported for normal individuals. Increased plasma lead concentrations do not seem to cause a significant deposition of lead in skeletal muscle. Therefore, plasma rather than skeletal muscle is the more likely source if pathological amounts of lead enter the motoneurones via the retrograde axoplasmic flow in amyotrophic lateral sclerosis.
摘要
采用无火焰原子吸收分光光度法测定了肌萎缩侧索硬化症患者和对照受试者股外侧肌中的铅浓度。两组之间未发现统计学上的显著差异，且两组数据的量级与之前报道的正常个体的数据相同。血浆铅浓度升高似乎不会导致铅在骨骼肌中显著沉积。因此，在肌萎缩侧索硬化症中，如果病理量的铅通过逆行轴浆流进入运动神经元，那么血浆而非骨骼肌更有可能是铅的来源。
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本文引用的文献
1
Abnormal trace metals in man: lead.人体中的异常痕量金属：铅。
J Chronic Dis. 1961 Oct;14:408-25. doi: 10.1016/0021-9681(61)90139-4.
2
Lead concentrations in human tissues.人体组织中的铅浓度。
Br J Ind Med. 1970 Oct;27(4):339-51. doi: 10.1136/oem.27.4.339.
3
Lead content of neuromuscular tissue in amyotrophic lateral sclerosis: case report and other considerations.肌萎缩侧索硬化症中神经肌肉组织的铅含量：病例报告及其他考量
Br J Ind Med. 1974 Oct;31(4):275-87. doi: 10.1136/oem.31.4.275.
4
Heavy metals in normal Japanese tissues. Amounts of 15 heavy metals in 30 subjects.正常日本人体组织中的重金属。30名受试者体内15种重金属的含量。
Arch Environ Health. 1975 Oct;30(10):487-94. doi: 10.1080/00039896.1975.10666759.
5
Lead in human tissues.人体组织中的铅。
Toxicol Appl Pharmacol. 1975 Jun;32(3):638-51. doi: 10.1016/0041-008x(75)90127-1.
6
Abnormal tissue distribution of lead in amyotrophic lateral sclerosis.肌萎缩侧索硬化症中铅的异常组织分布。
J Neurol Sci. 1976 Oct;29(2-4):259-65. doi: 10.1016/0022-510x(76)90175-1.
7
Kinetic analysis of lead metabolism in healthy humans.健康人体铅代谢的动力学分析
J Clin Invest. 1976 Aug;58(2):260-70. doi: 10.1172/JCI108467.
8
Serum protein binding of lead in vitro in amyotrophic lateral sclerosis patients and controls.肌萎缩侧索硬化症患者和对照组体外铅的血清蛋白结合情况。
J Neurol Sci. 1978 Jun;37(1-2):95-105. doi: 10.1016/0022-510x(78)90230-7.
9
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10
Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood.
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